VISIT US IN CHICAGO JUNE 2-4 AT BOOTH 2073!

Dr. Wierda on Minimal Residual Disease in CLL

William G. Wierda, MD, PhD
Published: Thursday, Sep 17, 2015



William G. Wierda, MD, PhD, professor, Department of Leukemia, Division of Cancer Medicine, the University of Texas MD Anderson Cancer Center, discusses minimal residual disease in chronic lymphocytic leukemia (CLL). 

Wierda says that minimal residual disease-free status can be achieved with chemoimmunotherapy. Navitoclax, an oral small molecule inhibitor of BCL-2, is currently in development and has demonstrated good quality, deep remissions in clinical trials. Other small molecule inhibitors show excellent, long-term disease control. However, they do not show good, deep remission, but rather partial remissions, explains Wierda.

The chemoimmuntherapy data, investigated by Wierda and his colleagues, has demonstrated the potential for a good number of patients to achieve complete remission. For these types of patients, a significant proportion achieve minimal residual disease-free status in the bone marrow, when evaluated by four-color flow cytometry, says Wierda.



William G. Wierda, MD, PhD, professor, Department of Leukemia, Division of Cancer Medicine, the University of Texas MD Anderson Cancer Center, discusses minimal residual disease in chronic lymphocytic leukemia (CLL). 

Wierda says that minimal residual disease-free status can be achieved with chemoimmunotherapy. Navitoclax, an oral small molecule inhibitor of BCL-2, is currently in development and has demonstrated good quality, deep remissions in clinical trials. Other small molecule inhibitors show excellent, long-term disease control. However, they do not show good, deep remission, but rather partial remissions, explains Wierda.

The chemoimmuntherapy data, investigated by Wierda and his colleagues, has demonstrated the potential for a good number of patients to achieve complete remission. For these types of patients, a significant proportion achieve minimal residual disease-free status in the bone marrow, when evaluated by four-color flow cytometry, says Wierda.




View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
34th Annual Miami Breast Cancer Conference® Clinical Case Vignette Series™May 25, 20182.0
Community Practice Connections™: CDK4/6 Inhibitors With the Experts: The Role of Emerging Agents for the Management of Metastatic Breast CancerMay 30, 20182.0
Publication Bottom Border
Border Publication
x