Dr. Wong on Antibody-Drug Conjugate Research in Multiple Myeloma

Sandy Wong, MD
Published: Wednesday, Jan 22, 2020



Sandy Wong, MD, assistant professor, University of California, San Francisco (UCSF) School of Medicine, UCSF Helen Diller Family Comprehensive Cancer Center, discusses the ongoing research of antibody-drug conjugates (ADCs) in multiple myeloma.

The ADC that is furthest along is belantamab mafodotin, which is directed against BCMA, explains Wong. Data from the phase I DREAMM-1 trial showed a response rate of 60% in heavily pretreated patients with relapsed/refractory multiple myeloma. Additionally, the median progression-free survival was 12 months.

In January 2020, the FDA granted a priority review designation to belantamab mafodotin based on findings from the DREAMM-2 trial, which showed the drug had an overall response rate (ORR) of 31% in patients with relapsed/refractory multiple myeloma who received the treatment at the recommended 2.5 mg/kg dose. The ORR in patients who received belantamab mafodotin at 3.4 mg/kg was 34%.

Belantamab mafodotin is associated with corneal toxicities, but it seems they are reversible with supportive care and withholding the drug, concludes Wong.
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Sandy Wong, MD, assistant professor, University of California, San Francisco (UCSF) School of Medicine, UCSF Helen Diller Family Comprehensive Cancer Center, discusses the ongoing research of antibody-drug conjugates (ADCs) in multiple myeloma.

The ADC that is furthest along is belantamab mafodotin, which is directed against BCMA, explains Wong. Data from the phase I DREAMM-1 trial showed a response rate of 60% in heavily pretreated patients with relapsed/refractory multiple myeloma. Additionally, the median progression-free survival was 12 months.

In January 2020, the FDA granted a priority review designation to belantamab mafodotin based on findings from the DREAMM-2 trial, which showed the drug had an overall response rate (ORR) of 31% in patients with relapsed/refractory multiple myeloma who received the treatment at the recommended 2.5 mg/kg dose. The ORR in patients who received belantamab mafodotin at 3.4 mg/kg was 34%.

Belantamab mafodotin is associated with corneal toxicities, but it seems they are reversible with supportive care and withholding the drug, concludes Wong.



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