Dr. Yardley Discusses CDK4/6 Inhibitors for Breast Cancer

Denise A. Yardley, MD
Published: Monday, Oct 30, 2017



Denise A. Yardley, MD, senior investigator of breast cancer research, Sarah Cannon Research Institute, discusses CDK4/6 inhibitors for patients with breast cancer.

PALOMA-1 data investigated the clinical science of CDK4/6 inhibitors and demonstrated that they could affect outcomes and double the disease-free survival for patients with hormone receptor-positive breast cancer. The PALOMA-1 trial led to the accelerated approval of palbociclib (Ibrance) in the first-line setting for that patient population.

The confirmatory PALOMA-2 trial further demonstrated that the signal seen with CDK4/6 inhibitors was real and reproducible. PALOMA-3 investigated patients who had failed prior endocrine therapy and then received fulvestrant (Faslodex) with a CDK4/6 inhibitor.
 


Denise A. Yardley, MD, senior investigator of breast cancer research, Sarah Cannon Research Institute, discusses CDK4/6 inhibitors for patients with breast cancer.

PALOMA-1 data investigated the clinical science of CDK4/6 inhibitors and demonstrated that they could affect outcomes and double the disease-free survival for patients with hormone receptor-positive breast cancer. The PALOMA-1 trial led to the accelerated approval of palbociclib (Ibrance) in the first-line setting for that patient population.

The confirmatory PALOMA-2 trial further demonstrated that the signal seen with CDK4/6 inhibitors was real and reproducible. PALOMA-3 investigated patients who had failed prior endocrine therapy and then received fulvestrant (Faslodex) with a CDK4/6 inhibitor.
 

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TitleExpiration DateCME Credits
Clinical Interchange™: Translating Research to Inform Changing Paradigms: Assessment of Emerging Immuno-Oncology Strategies and Combinations across Lung, Head and Neck, and Bladder CancersOct 31, 20182.0
Community Practice Connections: Oncology Best Practice™ Targeting Cell Cycle Progression: The Latest Advances on CDK4/6 Inhibition in Metastatic Breast CancerOct 31, 20181.0
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