Treatment Advancements in Newly Diagnosed and Relapsed/Refractory in Multiple Myeloma

Panelists discuss how quadruplet-based induction therapy, including anti-CD38 monoclonal antibodies, is becoming the preferred frontline treatment for transplant-eligible patients with multiple myeloma based on risk stratification.

Panelists discuss how data from the PERSEUS trial supports the use of daratumumab in quadruplet regimens to improve sustained minimal residual disease negativity and progression-free survival in transplant-eligible myeloma patients.

Panelists discuss how treating newly diagnosed, transplant-ineligible multiple myeloma patients requires a nuanced approach that accounts for comorbidities, age, and functional status to optimize induction therapy.

Panelists analyses from the CEPHEUS suggest that quadruplet regimens provide broad benefits in transplant-ineligible patients, though ultra–high-risk subtypes may require novel strategies discuss how subgroup.

Panelists discuss how isatuximab-containing quadruplet regimens offer clinical benefit in patients with 1q gain or amplification, though its advantage appears to reflect a class effect among CD38-targeting agents.

Panelists discuss how novel agents like iberdomide show promising efficacy and manageable toxicity in early-phase studies for transplant-ineligible patients with newly diagnosed multiple myeloma (NDMM).

Panelists discuss how the evolving treatment landscape, including CAR T-cell therapy and bispecifics, has made it possible to offer cellular therapies like cilta-cel as early as second-line treatment for eligible patients.

Panelists discuss how novel agents like iberdomide show promising efficacy and manageable toxicity in early-phase studies for transplant-ineligible patients with newly diagnosed multiple myeloma (NDMM).

Panelists discuss how 5-year follow-up data from the CARTITUDE-1 trial demonstrate durable responses and potential functional cures in a subset of relapsed/refractory myeloma patients treated with cilta-cel.

Panelists discuss how updated data from the DREAMM-7 and DREAMM-8 studies validate the early integration of BCMA-targeted therapies like belantamab mafodotin, showing promising efficacy and manageable ocular toxicities.

Panelists discuss how sequencing CAR T-cell therapy, bispecifics, and antibody-drug conjugates (ADCs) will become increasingly complex, with treatment decisions depending on patient characteristics, accessibility, and toxicity profiles.

Panelists discuss how subgroup analyses of cilta-cel support its efficacy in high-risk cytogenetics and extramedullary disease, though bridging therapy and patient selection remain key for optimal outcomes.

Panelists discuss how the CARTITUDE-4 data support early use of ide-cel in triple class–exposed myeloma patients, emphasizing the importance of avoiding attrition by not delaying highly effective therapies.

Panelists discuss how extended follow-up from the MonumenTAL-1 trial confirms the durable efficacy and favorable infection profile of talquetamab, while ongoing trials like TALISMAN aim to mitigate its unique toxicity profile.

Panelists discuss how dual-targeting bispecific therapies, exemplified by JNJ-78934804 (targeting BCMA and GPRC5D), show early potential to redefine treatment paradigms in heavily pretreated multiple myeloma, with impressive response rates and manageable safety profiles.

Panelists discuss how evolving therapeutic strategies, including the use of quadruplet regimens and emerging trispecific antibodies, may lead to functional cures in multiple myeloma and shift treatment goals toward finite-duration therapy.