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Opinion|Videos|June 27, 2025

CEPHEUS Subgroup Analyses: Insights From ASCO 2025

Author(s)Luciano J. Costa, MD, PhD, Jing Christine Ye, MD, MSc , Samer Al Hadidi, MD, MS

Panelists analyses from the CEPHEUS suggest that quadruplet regimens provide broad benefits in transplant-ineligible patients, though ultra–high-risk subtypes may require novel strategies discuss how subgroup.

Episodes in this series

4 experts are featured in this series.

EP. 1 Managing Transplant-Eligible NDMM: Current Treatments

4 experts are featured in this series.

EP. 2 ASCO 2025: Updates From PERSEUS, ADVANCE, and Other Trials in Transplant-Eligible NDMM

4 experts are featured in this series.

EP. 3 Management Approaches and Unmet Needs in Transplant-Ineligible NDMM

4 experts are featured in this series.

EP. 4 CEPHEUS Subgroup Analyses: Insights From ASCO 2025

4 experts are featured in this series.

EP. 5 Targeted Insights: IMROZ Trial and the Role of 1q21+ and MRD/PET-CT

4 experts are featured in this series.

EP. 6 Emerging Data in Transplant-Ineligible NDMM: DREAMM-10, ENDURANCE, and CC-220-MM-001

4 experts are featured in this series.

EP. 7 Navigating the Current Landscape of Relapsed/Refractory Multiple Myeloma

4 experts are featured in this series.

EP. 8 Real-World Decision-Making: Triplet vs Quadruplet in NDMM-TI

4 experts are featured in this series.

EP. 9 ASCO 2025 Insights: CARTITUDE-1–– Long-Term Follow-Up

4 experts are featured in this series.

EP. 10 ASCO Insights: Experts Discuss Recent DREAMM-7 and DREAMM-8 Data

4 experts are featured in this series.

EP. 11 Positioning ADCs and CAR T in R/R Multiple Myeloma

4 experts are featured in this series.

EP. 12 CARTITUDE-4 Subgroup Analysis: When Cilta-Cel Should Be Considered

4 experts are featured in this series.

EP. 13 Insights Into CAR T Therapy in Earlier vs Later Lines

4 experts are featured in this series.

EP. 14 Talquetamab: Efficacy, AE Management, and Outpatient Strategies and Insights From ASCO 2025

4 experts are featured in this series.

EP. 15 BCMA Bispecifics in the Clinic: Data, Toxicities, and Real-World Experience

4 experts are featured in this series.

EP. 16 Emerging Approaches and Key Takeaways in R/R MM: Insights from ASCO 2025

Quadruplets for Older Patients and High-Risk Cytogenetics
Recent analyses from the IFM and EMN studies suggest that quadruplet therapy benefits not just younger, fit patients, but also those who are older or considered transplant-deferred. These findings challenge traditional categorizations of transplant eligibility.

In-depth subgroup analyses show that the benefits of quad therapy extend across ISS staging and age groups. However, patients with ultra–high-risk cytogenetics (eg, del(17p), t(4;14)) continue to experience poor outcomes even with enhanced induction, indicating persistent unmet needs.

Clinicians now consider early use of novel agents and dual maintenance strategies for high-risk, nontransplant candidates. A more nuanced approach to treatment planning is emerging, guided by cytogenetic profiles and functional assessments rather than strict age cutoffs.

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