Updates in HR+ HER2- Advanced or Metastatic Breast Cancer

EP. 1: Identifying PIK3CA Mutations in HR+ HER2- MBC
ByJoyce O'Shaughnessy, MD, Baylor-Sammons Cancer Center,Gabriel Hortobagyi, MD, MACP, FASCO,Neil M. Iyengar, MD,Sarah Sammons, MD, Duke Cancer Institute Kicking off a discussion regarding recent data presented at ESMO 2021, a panel of breast oncologists share their preferences for conducting molecular testing to identify mutations such as PIK3CA that can help determine how to treat patients with HR+/HER2- metastatic breast cancer.

EP. 2: HR+ MBC: Prognostic Factors and Treatment Planning
ByJoyce O'Shaughnessy, MD, Baylor-Sammons Cancer Center,Gabriel Hortobagyi, MD, MACP, FASCO,Neil M. Iyengar, MD,Sarah Sammons, MD, Duke Cancer Institute Dr. Neil Iyengar highlights variables that factor into treatment decisions for patients with HR+/HER2- metastatic breast cancer.

A panel of breast oncologists review first-line treatment options for patients with HR+/HER2- metastatic breast cancer, commenting on treatment advances utilizing CKD4/6 inhibitors.

Reactions to new overall survival results from the MONALEESA-2 study in patients with HR+/HER2- advanced breast cancer in the first-line setting.

Considerations regarding the association of quality of life with overall survival in patients with HR+/HER2- advanced breast cancer treated with ribociclib and endocrine therapy.

Insight on how to best sequence therapy for patients with HR+/HER2- advanced breast cancer based on updated data from the MONALEESA trials.

Dr. Sarah Sammons highlights various first-line treatment approaches that combine CDK4/6 inhibitors with endocrine therapy as treatment for HR+/HER2- metastatic breast cancer.

EP. 8: HR+/HER2- MBC: CKD4/6 Inhibitor Treatment Toxicities
ByJoyce O'Shaughnessy, MD, Baylor-Sammons Cancer Center,Neil M. Iyengar, MD,Sarah Sammons, MD, Duke Cancer Institute,Gabriel Hortobagyi, MD, MACP, FASCO Clinical pearls regarding best practices preventing and/or managing common treatment-related adverse events associated with CDK4/6 inhibitors used to treat HR+/HER2- metastatic breast cancer.

Similarities and differences between available CDK4/6 inhibitors used to treat HR+/HER2- metastatic breast cancer.

EP. 10: CDK4/6 Treatment Selection for HR+/HER2- MBC
ByJoyce O'Shaughnessy, MD, Baylor-Sammons Cancer Center,Gabriel Hortobagyi, MD, MACP, FASCO,Sarah Sammons, MD, Duke Cancer Institute,Neil M. Iyengar, MD The impact of recent data presented at ESMO 2021 in terms of selecting an appropriate CDK4/6 inhibitor as first-line treatment of HR+/HER2- metastatic breast cancer.

The rationale for investigating the role of therapies that target the PI3K pathway in HR+/HER2- metastatic breast cancer.

Considerations for treating patients with HR+/HER2- metastatic breast cancer with alpelisib, a PI3K inhibitor, following frontline treatment with a CDK4/6 inhibitor.

Breast oncologists share pearls regarding best practices treating patients with HR+/HER2- metastatic breast cancer with PI3K inhibitor therapy and mitigating treatment-related adverse events.

Strategies to help breast oncologists counsel patients on metabolic conditions when treating patients with HR+/HER2- metastatic breast cancer with PI3K inhibitors.

Variables that impact how breast oncologists should sequence therapies when managing patients with HR+/HER2- metastatic breast cancer.

A panel of breast oncologists highlight exciting treatment strategies being explored in clinical trials to help address treatment limitations in HR+/HER2- metastatic breast cancer.

Final takeaways from a discussion on best practices treating HR+/HER2- metastatic breast cancer with CDK4/6 inhibitors and PI3K therapies based on data presented at ESMO 2021.