Theresa Keegan, PhD, MS
Cancer Epidemiology and Survivorship
Division of Hematology and Oncology
UC Davis Comprehensive Cancer Center Sacramento, CA
Advances in treatment and supportive care have resulted in substantial improvements in cancer survival and a growing number of cancer survivors in the United States. These survivors, however, are at an increased risk of developing a second cancer due to genetic factors, the carcinogenic effects of cancer treatment, common exposures (eg, tobacco), and other as yet unknown factors. The risk of developing a second cancer also varies by age, with those diagnosed with their first cancer during childhood having the highest risk. The burden of second cancers in survivors of adolescent and young adult (AYA) cancers (15-39 years) is also high; they have a higher risk of developing a second cancer than older cancer survivors and have the highest absolute excess risk of a second cancer, or excess cancers per 10,000 person-years, among all age groups.
Figure. Second Primary Malignancies
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