New Strategy Boosts Microenvironment to Promote Antitumor Immunity in GI Metastases

Ajay V. Maker, MD, FACS
Published: Monday, Jul 31, 2017
UI HealthAjay V. Maker, MD, FACS
 
Associate Professor, Surgery

The University of Illinois at Chicago

Chicago, IL

Strategic Partnership
Despite the promise of immunotherapy for treating patients with advanced cancers, the success of using such therapies for progressive gastrointestinal (GI) malignancies such as colorectal liver metastases (CRLM) has been limited so far. Previous research suggests that success has been restricted, in part, by a lack of known colon cancer-specific tumor antigens, dose-limiting toxicity, and immunoediting. Our team at the University of Illinois at Chicago (UIC) is approaching this problem by addressing the tumor microenvironment rather than identifying specific tumor antigens. We are looking to support immunostimulation of naturally occurring tumor-infiltrating lymphocytes (TILs) in the tumor environment.
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View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Community Practice Connections™: New Directions in Advanced Cutaneous Squamous Cell Carcinoma: Emerging Evidence of ImmunotherapyAug 13, 20191.5
Oncology Briefings™: Individualizing Treatment After Second-Line Therapy for Patients With mCRCAug 29, 20191.0
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