Researchers have concluded from an analysis of multiple studies that the fecal immunochemical test (FIT) has high overall diagnostic accuracy for screening asymptomatic patients at an increased risk for colorectal cancer (CRC) and moderate accuracy for diagnosing advanced neoplasia (AN). The findings are important because colonoscopy is currently the only recommended screening modality for patients at increased risk of CRC, such as those with a personal or family history of CRC.
Investigators stressed the need for future studies that include larger and better-defined patient populations, the establishment of optimal thresholds, test cutoff values, and guidelines for the number and frequency of FIT samples.
Katsoula A, Paschos P, Haidich AB, Tsapas A, Giouleme O. Diagnostic accuracy of fecal immunochemocal test in patients at increased risk for colorectal cancer: a meta-analysis. JAMA Intern Med. 2017;177(8):1110- 118. doi: 10.1001/jamainternmed.2017.2309.
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