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Novel Immunotherapy Combos Target GITR to Step on the Gas

Jane De Lartigue, PhD
Published: Monday, Oct 21, 2019
Immunotherapies designed to exploit the host immune system to specifically target cancer cells exploded onto the oncology scene in the mid-1980s, when the first such agents started to show success in melanoma and renal cell carcinoma.1 In particular, immune checkpoint inhibitors (ICIs), which block signals that dampen T-cell activity, are a major breakthrough, yielding the possibility of long-term clinical benefit across a growing number of tumor types.2
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