Maurie Markman, MD
Stunning technological advances in the ability to examine the molecular structure of human DNA have significantly reduced the time and costs associated with this process. Understandably, cancer investigators have been preoccupied with sifting for genetic information that might lead to favorable therapeutic action. Thus, not surprisingly, a large majority of clinical investigations have focused on mutations or other molecular aberrations within the cancer itself, rather than genomic data present in an individual’s germline. An increasing number of high-quality academic and commercial efforts have been designed to discover relevant cancer-related molecular events and corresponding antineoplastic strategies that can effectively target those abnormalities. These have achieved major success in multiple clinical settings.
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