Catherine H. Marshall, MD, MPH
Combination therapy with radium-223 (Xofigo) and sipuleucel-T (Provenge) yielded conflicting results in patients with metastatic castration-resistant prostate cancer (mCRPC), according to data shared at the 2020 Genitourinary Cancers Symposium. The regimen enhanced clinical outcomes across several key benchmarks compared with sipuleucel-T alone; however, immune responses were superior with single-agent sipuleucel-T versus the doublet.
Adverse event rates were similar between the 2 groups, including constitutional, hematologic, gastrointestinal, cardiac, and others.
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- Marshall CH, Park JC, Fu W, et al. Randomized phase 2 study of sipuleucel-T (Sip-T) with or without radium-223 (Ra-223) in men with bone-metastatic castration resistant prostate cancer. Presented at: 2020 Genitourinary Cancers Symposium; February 13-15, 2020; San Francisco, CA. Abstract 130.
- Shore ND, Mantz CA, Dosoretz DE, et al. Building on sipuleucel-T for immunologic treatment of castration-resistant prostate cancer. Cancer Control. 2013;20(1):7-16.
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