Translating Combination Radiotherapy/Immunotherapy From Dogs to Humans With Advanced Melanoma or Sarcoma

By Arta Monjazeb, MD, and Michael Kent, DVM
Published: Wednesday, May 29, 2013
UC Davis Comprehensive Cancer Center Dr. Arta Monjazeb
Arta Monjazeb, MD

Dr. Michael Kent
Michael Kent, DVM
UC Davis Comprehensive Cancer Center, Sacramento, California Dr. Yixuan Gong
With few exceptions, metastatic sarcomas and melanomas are incurable. At UC Davis Comprehensive Cancer Center, we have embarked on a novel study to improve these odds by combining radiotherapy and immune therapy. The research has shown good results so far in laboratory mice and promising results in a preliminary clinical trial of companion dogs with spontaneous tumors.

Patients with metastatic melanoma or with metastatic sarcoma are typically treated with chemotherapy, but with very limited success. Our approach harnesses the immune system to recognize the cancer and eliminate it as it would an infection.

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