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Advances in the Treatment of Relapsed or Refractory Hairy Cell Leukemia

Published: Friday, Jul 12, 2019
Hairy cell leukemia (HCL) is a rare mature B-cell malignancy that accounts for 2% of all leukemias, translating to approximately 1000 new cases reported each year in the United States.1 In HCL, the bone marrow, spleen, and liver are infiltrated by mature B cells, characterized by ample cytoplasm with thin surface projections (giving rise to the descriptive name “hairy” cell leukemia)2 and a specific surface immunophenotype (coexpression of CD103, CD25, CD123, and CD11c).3,4
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