Continued Survival Benefits Observed With Encorafenib/Binimetinib Combo in Advanced Melanoma

Wayne Kuznar
Published: Wednesday, Jun 12, 2019
Helen J. Gogas, MD, PhD

Helen J. Gogas, MD, PhD

Updated results from the phase III COLUMBUS trial show continued prolonged progression-free and overall survival (OS) with the combination of encorafenib (Braftovi) and binimetinib (Mektovi) compared with BRAF inhibition alone in patients with advanced/metastatic BRAF V600-mutant melanoma.

In part 1 of the international COLUMBUS study, 577 patients with BRAF V600E/K mutation-positive unresectable or metastatic melanoma were randomized 1:1:1 to receive encorafenib 450 mg twice daily in combination with binimetinib 45 mg twice daily (n = 192), encorafenib alone at 300 mg daily (n = 194), or vemurafenib 960 mg twice daily (n = 191).
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