Targeting BCL-2 in Hematologic Malignancies

Published: Friday, Jan 11, 2019
The BCL-2 family of proteins are central regulators of apoptosis, programmed cell death, which can occur in response to intrinsic stress signals or environmental cues. During the life span of any organism, proliferation must be balanced with apoptosis, to ensure both appropriate development and proper, mature physiologic cell and organ function. This balance between proliferation and apoptosis is particularly important in such highly proliferative tissues as the bone marrow.1 Deregulation of apoptotic pathways can lead to cancer, with resistance to apoptosis having been identified as a hallmark of human cancer nearly 20 years ago.2 Over the past 2 decades, considerable efforts have focused on the development of therapies that can restore apoptosis in malignant cells.3 
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