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Opinion|Videos|December 20, 2024

Beyond T315I mutations: When to Consider Ponatinib or Asciminib in CML Second-Line Treatment

Author(s)Jorge Cortes, MD, Stephen A. Strickland, MD, MSCI

Panelists discuss how when choosing between asciminib and ponatinib for chronic myeloid leukemia treatment, key considerations include the patient’s mutation status, prior tyrosine kinase inhibitor therapy response, cardiovascular risk factors and comorbidities, and the differing safety profiles of the 2 drugs, with ponatinib generally having more cardiovascular concerns but broader mutation coverage vs asciminib’s more favorable tolerability but more specific targeting of BCR::ABL1.

Episodes in this series

2 experts in this video

EP. 1 Evaluating Early Treatment Response in CML: Expert Insights on Monitoring

2 experts in this video

EP. 2 Interpreting Milestones: Prioritizing the Patient Picture

2 experts in this video

EP. 3 Managing T315I Mutations in CML: Second Line Treatment Options - Ponatinib & Asciminib

2 experts in this video

EP. 4 Beyond T315I mutations: When to Consider Ponatinib or Asciminib in CML Second-Line Treatment

2 experts in this video

EP. 5 Managing Adverse Events: Ponatinib & Asciminib in CML: Expert Approaches

2 experts in this video

EP. 6 Choosing First-Line TKI Therapy for CML: Expert Approaches to Risk Assessment & Treatment Selection

2 experts in this video

EP. 7 ASC4FIRST Trial & Asciminib New FDA Approval: Evaluating Asciminib in First-Line CML Treatment

2 experts in this video

EP. 8 Key Takeaways: The Current Landscape and Future of CML Care

Video content above is prompted by the following:

What do you consider when making a treatment decision between asciminib and ponatinib?
What disease-specific factors do you consider?
What patient factors do you consider?

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