Opinion|Videos|December 20, 2024
Managing T315I Mutations in CML: Second Line Treatment Options - Ponatinib & Asciminib
Panelists discuss how for patients with chronic myeloid leukemia who develop the T315I mutation, ponatinib and asciminib have demonstrated efficacy in the PACE and ASCEMBL trials, respectively, with ponatinib showing a major cytogenetic response rate in patients with T315I mutation and asciminib demonstrating superior major molecular response vs bosutinib.
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Video content above is prompted by the following:
- We know that a T315I mutation in the kinase domain confers resistance to our frontline therapies for chronic myeloid leukemia (bosutinib, dasatinib, imatinib, and nilotinib). What therapies are available for patients who develop this mutation while taking their first-line tyrosine kinase inhibitor?
- Please briefly review the ASCEMBL and PACE trials and key outcomes.
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