Case Presentation: A 68-Year-Old Man With Resected High-Risk Cutaneous Squamous Cell Carcinoma

Dr Whitman presents the first clinical scenario, a 68-year-old man with a cutaneous squamous cell carcinoma of the temple who has undergone resection. The tumor demonstrates several adverse pathologic features, including perineural invasion and nodal involvement with extracapsular extension, and the patient has completed adjuvant radiation therapy. Dr In walks through his initial assessment of the case, identifying which specific features drive his concern for recurrence and how he communicates that risk to a patient who has just finished definitive local therapy and may feel treatment is behind him. The faculty map the case against the C-POST eligibility criteria, with Dr Whitman observing that the patient represents a close, if somewhat constructed, fit for adjuvant checkpoint inhibitor therapy. The segment demonstrates how high-risk pathologic features translate into a concrete recommendation for adjuvant systemic treatment in routine cutaneous oncology practice.