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Opinion|Videos|January 31, 2025

Clinical Insights: Key Data Presented at ASH 2024 in MDS

Author(s)Courtney DiNardo, MD, MSCE, Rami Komrokji, MD, Amer Zeidan, MBBS, MHS

Panelists discuss how oral decitabine/cedazuridine demonstrated meaningful clinical activity in patients with TP53-mutated myelodysplastic syndromes (MDS), with a 31% complete response rate and 16.1-month median overall survival, representing an important treatment advance for this traditionally poor-prognosis molecular subgroup.

Episodes in this series

3 experts are featured in this series.

EP. 1 Evolving Horizons: MDS Diagnosis and Risk Stratification in 2024

3 experts are featured in this series.

EP. 2 MDS Treatment Strategies: From Risk Assessment to Transplantation

3 experts are featured in this series.

EP. 3 Introducing Hypomethylating Agents for Patients With MDS

3 experts are featured in this series.

EP. 4 ASCERTAIN Trial: Key Data of Oral Decitabine and Cedazuridine in MDS

3 experts are featured in this series.

EP. 5 Comparison of Oral vs Intravenous Hypomethylating Agents in the Treatment of MDS

3 experts are featured in this series.

EP. 6 Clinical Insights: Key Data Presented at ASH 2024 in MDS

3 experts are featured in this series.

EP. 7 A Deep Dive Into Treatment Approaches for Patients With MDS by Risk Status

3 experts are featured in this series.

EP. 8 Future Horizons in the Treatment of Myelodysplastic Syndromes

Video content above is prompted by the following:

• Can you share any key takeaways or additional data updates surrounding MDS presented at ASH 2024?
• Oral decitabine/cedazuridine in MDS and TP53 mutations.

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