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Opinion|Videos|January 31, 2025

Comparison of Oral vs Intravenous Hypomethylating Agents in the Treatment of MDS

Author(s)Courtney DiNardo, MD, MSCE, Rami Komrokji, MD, Amer Zeidan, MBBS, MHS

Panelists discuss how oral decitabine/cedazuridine showed encouraging efficacy in patients with myelodysplastic syndromes (MDS) with TP53 mutations, suggesting this oral formulation could be particularly beneficial for this historically difficult-to-treat molecular subgroup.

Episodes in this series

3 experts are featured in this series.

EP. 1 Evolving Horizons: MDS Diagnosis and Risk Stratification in 2024

3 experts are featured in this series.

EP. 2 MDS Treatment Strategies: From Risk Assessment to Transplantation

3 experts are featured in this series.

EP. 3 Introducing Hypomethylating Agents for Patients With MDS

3 experts are featured in this series.

EP. 4 ASCERTAIN Trial: Key Data of Oral Decitabine and Cedazuridine in MDS

3 experts are featured in this series.

EP. 5 Comparison of Oral vs Intravenous Hypomethylating Agents in the Treatment of MDS

3 experts are featured in this series.

EP. 6 Clinical Insights: Key Data Presented at ASH 2024 in MDS

3 experts are featured in this series.

EP. 7 A Deep Dive Into Treatment Approaches for Patients With MDS by Risk Status

3 experts are featured in this series.

EP. 8 Future Horizons in the Treatment of Myelodysplastic Syndromes

Video content above is prompted by the following:

• Can you share any key takeaways or additional data updates surrounding MDS presented at ASH 2024?
• Oral decitabine/cedazuridine in MDS and TP53 mutations.

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