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The risk of developing ICANS with CAR T-cell therapy was higher in patients with NHL who experienced a recent fall and could not balance on their left leg.

Physical Functioning Measures May Predict Survival Outcomes, ICANS Risk With CAR T-Cell Therapy in NHL

Real-world data showed that atezolizumab provided a benefit and was safe in patients with platinum-ineligible mUC and high comorbidities/functional status.

First-Line Atezolizumab Is Suitable in Platinum-Based Chemotherapy Ineligible mUC 

Tanya Gupta, MD, highlights the utility of adjuvant CDK4/6 and PARP inhibitors in patients with HR-positive, HER2-negative breast cancer.

Adjuvant CDK4/6 Inhibitors Lay a Solid Treatment Foundation in HR+, HER2– Breast Cancer

Ocular adverse effects stemming from mirvetuximab soravtansine did not significantly affect HRQOL in FRα-positive platinum-resistant ovarian cancer.

Ocular AEs From Mirvetuximab Soravtansine Do Not Impact HRQOL in FRα+ Platinum-Resistant Ovarian Cancer

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Megan Hollasch joined MJH Life Sciences in 2022 following graduation from the University of Massachusetts Amherst with majors in Communication and English, and a specialization in Literature as History. She produces and edits original content for the print publication 

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Divarasib Looks to Best Sotorasib/Adagrasib and Solidify a Role in KRAS G12C-Mutated NSCLC 

Moffitt Cancer Center researchers found a way to boost cancer immunotherapy by targeting a protein called macrophage receptor with collagenous structure.

Moffitt Study Finds New Immunotherapy Strategy for Enhancing Melanoma Treatment

Jax DiEugenio joined MJH Life Sciences in 2024, first as an editorial intern before transitioning into a full-time assistant editor for 

. A recent College of New Jersey graduate, Jax majored in Journalism/ Professional Writing with minors in Public Health and Anthropology. He is also pursuing a Master's Degree in Public Health, concentrating on health communications.

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, and helps ensure timely publication of news content and announcements from the FDA approval pipeline. She also attends conferences live and virtually to conduct video interviews and produce written coverage. Email: awahner@mjhlifesciences.com

A Type II variation application has been submitted to the EMA for the expanded approval of sugemalimab for unresectable stage III NSCLC.

EMA to Review Application for Expanded Indication for Sugemalimab in Unresectable NSCLC

The combination of toripalimab and bevacizumab has been approved in China for the treatment of patients with unresectable or metastatic HCC. 

NMPA Approves sNDA for Toripalimab Plus Bevacizumab in Advanced HCC

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Evolving Practices for Myelodysplastic Syndromes (MDS): Highlights from ASH 2024 and Beyond 

Clinical

Video Series

Introducing Hypomethylating Agents for Patients With MDS

Video content above is prompted by the following:

Please provide a brief overview of hypomethylating agents for patients with intermediate- to high-risk MDS.

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The panelists discuss the newest risk stratification tool, IPSS-M. 

Evolving Horizons: MDS Diagnosis and Risk Stratification in 2024

Panelists discuss how the primary therapeutic goals for patients with intermediate- to high-risk myelodysplastic syndromes (MDS) focus on extending survival and modifying disease course through intensive treatments like hypomethylating agents or stem cell transplantation while addressing unique challenges such as treatment resistance, poor response durability, and limited options after hypomethylating agents failure.

MDS Treatment Strategies: From Risk Assessment to Transplantation

Panelists discuss how hypomethylating agents remain the cornerstone of therapy for intermediate to high-risk patients with myelodysplastic syndromes (MDS).

Panelists discuss how the ASCERTAIN trial demonstrated that oral decitabine plus cedazuridine provided comparable efficacy to injectable decitabine.

ASCERTAIN Trial: Key Data of Oral Decitabine and Cedazuridine in MDS

Panelists discuss how oral decitabine/cedazuridine showed encouraging efficacy in patients with myelodysplastic syndromes (MDS) with TP53 mutations, suggesting this oral formulation could be particularly beneficial for this historically difficult-to-treat molecular subgroup.

Comparison of Oral vs Intravenous Hypomethylating Agents in the Treatment of MDS

Panelists discuss how oral decitabine/cedazuridine demonstrated meaningful clinical activity in patients with TP53-mutated myelodysplastic syndromes (MDS), with a 31% complete response rate and 16.1-month median overall survival, representing an important treatment advance for this traditionally poor-prognosis molecular subgroup.

Clinical Insights: Key Data Presented at ASH 2024 in MDS

Panelists discuss how treatment strategies for myelodysplastic syndromes (MDS) are fundamentally guided by risk stratification, with lower-risk patients typically receiving supportive care and less intensive treatments focused on quality of life and symptom management while intermediate- to high-risk patients require more aggressive approaches, including hypomethylating agents and consideration for stem cell transplantation, with emerging data supporting novel combinations and targeted therapies across the risk spectrum.

A Deep Dive Into Treatment Approaches for Patients With MDS by Risk Status

Panelists discuss how the future treatment landscape for myelodysplastic syndromes (MDS) appears promising with several ongoing clinical trials exploring novel combinations and targeted therapies, including investigations of venetoclax combinations, magrolimab, sabatolimab, and other immune-based approaches that could potentially improve outcomes across different risk groups and molecular subtypes.

Introducing Hypomethylating Agents for Patients With MDS

EP: 1.Evolving Horizons: MDS Diagnosis and Risk Stratification in 2024

EP: 2.MDS Treatment Strategies: From Risk Assessment to Transplantation

EP: 3.Introducing Hypomethylating Agents for Patients With MDS

EP: 4.ASCERTAIN Trial: Key Data of Oral Decitabine and Cedazuridine in MDS

EP: 5.Comparison of Oral vs Intravenous Hypomethylating Agents in the Treatment of MDS

EP: 6.Clinical Insights: Key Data Presented at ASH 2024 in MDS

EP: 7.A Deep Dive Into Treatment Approaches for Patients With MDS by Risk Status

EP: 8.Future Horizons in the Treatment of Myelodysplastic Syndromes

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