
Opinion|Videos|January 3, 2025
Clinical Perspectives Selecting 2L Treatment Options in R/R FL: Chemoimmunotherapy vs Lenalidomide Combinations in Relapsed Disease
Panelists discuss how their treatment approaches in the second-line (2L) setting for relapsed or progressive follicular lymphoma (R/R FL) are influenced by factors such as the duration of response to first-line therapy, tumor burden, and symptomatology, while also exploring the use of chemoimmunotherapy, lenalidomide combinations, and anti-CD20 monotherapy in clinical decision-making.
Advertisement
Episodes in this series

Video content above is prompted by the following:
- For those with progression of disease, what is your treatment approach in the 2L setting? How do you factor in the duration of response to 1L therapy in selecting your 2L option as well as patient factors such as those with high tumor burden and/or symptomatic disease?
- How often are you utilizing chemoimmunotherapy with an anti-CD20 in the 2L setting? What percentage of your patients are receiving a bendamustine-based or cyclophosphamide-based regimen in the 1L setting?
- What is your treatment approach in selecting lenalidomide in combination with anti-CD20 vs anti-CD20 monotherapy?
- What patient and/or disease factors do you consider?
- Please feel free to comment on any differences and/or similarities in practice when selecting lenalidomide monotherapy vs in combination with anti-CD20 vs anti-CD20 monotherapy.
Advertisement
Related to this article

Did you catch all of this week's top oncology news? Test your knowledge with OncLive's Weekly News Quiz.

Durvalumab plus BCG is now an approved first-line option for high-risk NMIBC, but better BCG delivery and biomarker-guided selection should shape its use.

The FDA has approved amivantamab and hyaluronidase-lpuj for metastatic head and neck squamous cell carcinoma.

A UCLA-led study suggests routine mammograms or other breast imaging may not benefit women after double mastectomy for DCIS.
Advertisement
Advertisement
Trending on OncLive
1
FDA Approves Amivantamab and Hyaluronidase for Metastatic HNSCC
2
BCG Optimization Becomes a Priority as Durvalumab Gains a Role in High-Risk NMIBC
3
Dr Cai on the Rationale for Evaluating Rocbrutinib Plus R-CHOP in Non-GCB DLBCL and MCL
4
Dr Skoulidis on Divarasib vs Sotorasib or Adagrasib in KRAS G12C–Mutated NSCLC
5




