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Opinion|Videos|December 24, 2024

Clinical Scenario 1: A HER2+ mBC Patient With Trastuzumab Deruxtecan With Brain Mets

Panelists discuss how trastuzumab deruxtecan (Enhertu) is used to treat HER2-positive metastatic breast cancer with brain metastases, emphasizing its effectiveness in achieving systemic tumor reduction and CNS lesion stabilization while exploring treatment challenges and emerging strategies in this patient population.

Episodes in this series

EP. 1 Clinical Scenario 1: A HER2+ mBC Patient With Trastuzumab Deruxtecan With Brain Mets

EP. 1 Clinical Scenario 1: A HER2+ mBC Patient With Trastuzumab Deruxtecan With Brain Mets

EP. 2 Clinical Approaches in Treating HER2+ Breast Cancer and Brain Metastases

EP. 2 Clinical Approaches in Treating HER2+ Breast Cancer and Brain Metastases

EP. 3 T-DXd and the DESTINY-Breast12 Trial for HER2+ Advanced BC With or Without Brain Mets

EP. 3 T-DXd and the DESTINY-Breast12 Trial for HER2+ Advanced BC With or Without Brain Mets

EP. 4 The Impact of Trastuzumab Deruxtecan on Clinical Practice for HER2+ Advanced BC and Brain Mets

EP. 4 The Impact of Trastuzumab Deruxtecan on Clinical Practice for HER2+ Advanced BC and Brain Mets

EP. 5 The Influence of Systemic Metastases on Treatment Decision-Making for HER2+ BC With Brain Metastases

EP. 5 The Influence of Systemic Metastases on Treatment Decision-Making for HER2+ BC With Brain Metastases

EP. 6 Management of HER2+ Breast Cancer With Brain Relapse or Progression

EP. 6 Management of HER2+ Breast Cancer With Brain Relapse or Progression

EP. 7 HER2CLIMB-02 Trial: Exploring Tucatinib and T-DM1 for HER2+ mBC

EP. 7 HER2CLIMB-02 Trial: Exploring Tucatinib and T-DM1 for HER2+ mBC

EP. 8 Ongoing Trial(s) for Intracranial Progression in Advanced HER2+ Breast Cancer

EP. 8 Ongoing Trial(s) for Intracranial Progression in Advanced HER2+ Breast Cancer

EP. 9 Novel and Emerging Therapeutic Strategies for HER2+ Breast Cancer and Brain Metastases

EP. 9 Novel and Emerging Therapeutic Strategies for HER2+ Breast Cancer and Brain Metastases

Video content above is prompted by the following:

Do you agree with the above treatment plan? What would you have done differently?
What are your approaches to monitoring CNS disease?
Could you provide an overview of the treatment landscape for HER2-positive advanced breast cancer with brain metastases (BMs)?
Previous her pert , t_DM1 5 years ago 1^st RP3 study in breast cancer to include patients with active brain mets. 50% of patients. 60% untreated.
What challenges do you face in treating this patient population and what unmet needs remain?

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