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Opinion|Videos|January 21, 2025

The Impact of Trastuzumab Deruxtecan on Clinical Practice for HER2+ Advanced BC and Brain Mets

Panelists discuss how the DESTINY-Breast12 trial has influenced their approach to using trastuzumab deruxtecan (T-DXd) for patients with HER2-positive advanced breast cancer with brain metastases, highlighting the patient subgroups most likely to benefit from T-DXd and its impact on treatment sequencing for those with active brain metastases.

Episodes in this series

EP. 1 Clinical Scenario 1: A HER2+ mBC Patient With Trastuzumab Deruxtecan With Brain Mets

EP. 1 Clinical Scenario 1: A HER2+ mBC Patient With Trastuzumab Deruxtecan With Brain Mets

EP. 2 Clinical Approaches in Treating HER2+ Breast Cancer and Brain Metastases

EP. 2 Clinical Approaches in Treating HER2+ Breast Cancer and Brain Metastases

EP. 3 T-DXd and the DESTINY-Breast12 Trial for HER2+ Advanced BC With or Without Brain Mets

EP. 3 T-DXd and the DESTINY-Breast12 Trial for HER2+ Advanced BC With or Without Brain Mets

EP. 4 The Impact of Trastuzumab Deruxtecan on Clinical Practice for HER2+ Advanced BC and Brain Mets

EP. 4 The Impact of Trastuzumab Deruxtecan on Clinical Practice for HER2+ Advanced BC and Brain Mets

EP. 5 The Influence of Systemic Metastases on Treatment Decision-Making for HER2+ BC With Brain Metastases

EP. 5 The Influence of Systemic Metastases on Treatment Decision-Making for HER2+ BC With Brain Metastases

EP. 6 Management of HER2+ Breast Cancer With Brain Relapse or Progression

EP. 6 Management of HER2+ Breast Cancer With Brain Relapse or Progression

EP. 7 HER2CLIMB-02 Trial: Exploring Tucatinib and T-DM1 for HER2+ mBC

EP. 7 HER2CLIMB-02 Trial: Exploring Tucatinib and T-DM1 for HER2+ mBC

EP. 8 Ongoing Trial(s) for Intracranial Progression in Advanced HER2+ Breast Cancer

EP. 8 Ongoing Trial(s) for Intracranial Progression in Advanced HER2+ Breast Cancer

EP. 9 Novel and Emerging Therapeutic Strategies for HER2+ Breast Cancer and Brain Metastases

EP. 9 Novel and Emerging Therapeutic Strategies for HER2+ Breast Cancer and Brain Metastases

Video content above is prompted by the following:

How has the DESTINY-Breast12 trial impacted your view on using T-DXd for patients with HER2-positive advanced breast cancer and brain metastases?
Which patient subgroups are most likely to benefit from T-DXd, and how do these data influence treatment sequencing for those with active brain metastases?

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