
Opinion|Videos|January 28, 2025
Management of HER2+ Breast Cancer With Brain Relapse or Progression
Panelists discuss the management of HER2-positive breast cancer with brain relapse or progression, focusing on treatment strategies, challenges, and emerging therapies for improving outcomes in this patient population.
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Video content above is prompted by the following:
- How do you approach the management of patients with HER2-positive breast cancer with brain metastases who experience relapse or progression, and what factors guide your choice of therapy?
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Here is your cheat sheet to all therapeutic options that were cleared by the FDA in September 2026 spanning tumor types.

The FDA approved tucatinib plus trastuzumab and pertuzumab as maintenance for advanced HER2-positive breast cancer after induction.

The c-Met–directed ADC was designated for EGFR wild-type nonsquamous NSCLC after platinum chemotherapy and anti–PD-(L)1 therapy.

Dana-Farber’s Xin Gu, PhD, and Nicholas Polizzi, PhD, received NIH New Innovator Awards for high-risk, high-reward research.

The c-Met–directed ADC-based combination was designated for mCRC previously treated with fluoropyrimidine, irinotecan, oxaliplatin, and anti-VEGF therapy.

Pooled data from 3 randomized trials showed ropeginterferon alfa-2b improved responses vs phlebotomy alone but not vs hydroxyurea in polycythemia vera.
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