Opinion|Videos|April 22, 2026

Considerations for Targeted Agents and Rechallenge in R/R Follicular Lymphoma

Loretta J. Nastoupil, MD, and Amitkumar Mehta, MD, discuss the role of targeted therapies and rechallenging with certain classes of agents in follicular lymphoma.

Loretta J. Nastoupil, MD, and Amitkumar Mehta, MD, discuss considerations for targeted therapies and the role of rechallenge strategies in relapsed/refractory follicular lymphoma. Nastoupil reviews how prior exposure to CD19-directed therapies may influence subsequent treatment selection and sequencing. Mehta highlights emerging evidence on CD19 expression and the feasibility of reusing or sequencing targeted agents without compromising future efficacy.


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