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Opinion|Videos|April 21, 2025

ctDNA Biomarkers in INTRIGUE: Understanding Resistance Patterns

Author(s)Breelyn Wilky, MD, Jason Sicklick, MD, FACS, Seth M. Pollack, MD

Experts discuss the key insights from the follow-up exploratory analysis of the INTRIGUE trial investigating circulating DNA (ctDNA) biomarkers and how mutation-specific findings may influence molecular testing before selecting a second-line agent, with practical implications for implementing a more personalized approach in clinical practice.

Episodes in this series

EP. 1 Optimizing TKI Selection and Sequencing Strategies in Advanced GIST Beyond First-Line Therapy

EP. 1 Optimizing TKI Selection and Sequencing Strategies in Advanced GIST Beyond First-Line Therapy

EP. 2 Biological Mechanisms of GIST Resistance and Tumor Heterogeneity

EP. 2 Biological Mechanisms of GIST Resistance and Tumor Heterogeneity

EP. 3 Monitoring Tumor Heterogeneity and Detecting Resistance

EP. 3 Monitoring Tumor Heterogeneity and Detecting Resistance

EP. 4 Post-Imatinib Progression: Decision Factors and Treatment Options

EP. 4 Post-Imatinib Progression: Decision Factors and Treatment Options

EP. 5 INVICTUS Trial: Ripretinib in Fourth-Line Setting

EP. 5 INVICTUS Trial: Ripretinib in Fourth-Line Setting

EP. 6 INTRIGUE Trial: Key Findings in Second-Line Setting

EP. 6 INTRIGUE Trial: Key Findings in Second-Line Setting

EP. 7 ctDNA Biomarkers in INTRIGUE: Understanding Resistance Patterns

EP. 7 ctDNA Biomarkers in INTRIGUE: Understanding Resistance Patterns

EP. 8 Managing Adverse Events With Different TKIs

EP. 8 Managing Adverse Events With Different TKIs

EP. 9 Next-Generation Treatment Strategies for GIST: Evaluating Combination Therapies and Mutation-Specific Approaches

EP. 9 Next-Generation Treatment Strategies for GIST: Evaluating Combination Therapies and Mutation-Specific Approaches

EP. 10 Practical Recommendations for Community Oncologists

EP. 10 Practical Recommendations for Community Oncologists

Video content above is prompted by the following:

A follow-up exploratory analysis of the INTRIGUE trial investigated ctDNA biomarkers to better understand resistance patterns. Could you discuss the key insights from this analysis? How might these mutation-specific findings change our approach to molecular testing before selecting a second-line agent, and what are the practical implications for implementing this more personalized approach in clinical practice?

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