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Opinion|Videos|April 14, 2025

INTRIGUE Trial: Key Findings in Second-Line Setting

Author(s)Breelyn Wilky, MD, Jason Sicklick, MD, FACS, Seth M. Pollack, MD

Experts discuss the key findings from the INTRIGUE trial comparing ripretinib to sunitinib in the second-line setting, focusing on efficacy endpoints like progression-free survival (PFS) and PFS on next line of therapy, and interpret the patient-reported outcome (PRO) and tolerability data reported in the study.

Episodes in this series

EP. 1 Optimizing TKI Selection and Sequencing Strategies in Advanced GIST Beyond First-Line Therapy

EP. 1 Optimizing TKI Selection and Sequencing Strategies in Advanced GIST Beyond First-Line Therapy

EP. 2 Biological Mechanisms of GIST Resistance and Tumor Heterogeneity

EP. 2 Biological Mechanisms of GIST Resistance and Tumor Heterogeneity

EP. 3 Monitoring Tumor Heterogeneity and Detecting Resistance

EP. 3 Monitoring Tumor Heterogeneity and Detecting Resistance

EP. 4 Post-Imatinib Progression: Decision Factors and Treatment Options

EP. 4 Post-Imatinib Progression: Decision Factors and Treatment Options

EP. 5 INVICTUS Trial: Ripretinib in Fourth-Line Setting

EP. 5 INVICTUS Trial: Ripretinib in Fourth-Line Setting

EP. 6 INTRIGUE Trial: Key Findings in Second-Line Setting

EP. 6 INTRIGUE Trial: Key Findings in Second-Line Setting

EP. 7 ctDNA Biomarkers in INTRIGUE: Understanding Resistance Patterns

EP. 7 ctDNA Biomarkers in INTRIGUE: Understanding Resistance Patterns

EP. 8 Managing Adverse Events With Different TKIs

EP. 8 Managing Adverse Events With Different TKIs

EP. 9 Next-Generation Treatment Strategies for GIST: Evaluating Combination Therapies and Mutation-Specific Approaches

EP. 9 Next-Generation Treatment Strategies for GIST: Evaluating Combination Therapies and Mutation-Specific Approaches

EP. 10 Practical Recommendations for Community Oncologists

EP. 10 Practical Recommendations for Community Oncologists

Video content above is prompted by the following:

Please walk us through the key findings from the INTRIGUE trial comparing ripretinib to sunitinib in the second-line setting. What were the key efficacy end points evaluated in this study, and how did ripretinib perform compared to sunitinib on measures like PFS and PFS on next line of therapy? How do you interpret the PRO and tolerability data reported from INTRIGUE?

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