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Opinion|Videos|February 18, 2026

Data for Lenvatinib Plus Pembrolizumab and TACE in Unresectable, Nonmetastatic HCC

Author(s)Stephen Lam Chan, MBBS, MD, FRCP, FHKCP, FHKAM , Gonzalo Cantis, MD

Stephen Lam Chan, MBBS, MD, FRCP, FHKCP, FHKAM, and Gonzalo Cantis, MD, discuss data for lenvatinib, pembrolizumab, and TACE from LEAP-012 in HCC.

Episodes in this series

EP. 1 Current Approaches and Unmet Needs in Unresectable, Nonmetastatic HCC

EP. 1 Current Approaches and Unmet Needs in Unresectable, Nonmetastatic HCC

EP. 2 Data for Lenvatinib Plus Pembrolizumab and TACE in Unresectable, Nonmetastatic HCC

EP. 2 Data for Lenvatinib Plus Pembrolizumab and TACE in Unresectable, Nonmetastatic HCC

EP. 3 The Role of Lenvatinib/Pembrolizumab Plus TACE in China for Unresectable, Nonmetastatic HCC

EP. 3 The Role of Lenvatinib/Pembrolizumab Plus TACE in China for Unresectable, Nonmetastatic HCC

EP. 4 Systemic Therapy and Downstaging in Unresectable, Nonmetastatic HCC

EP. 4 Systemic Therapy and Downstaging in Unresectable, Nonmetastatic HCC

EP. 5 Other Novel Treatment Approaches in Unresectable, Nonmetastatic HCC

EP. 5 Other Novel Treatment Approaches in Unresectable, Nonmetastatic HCC

EP. 6 Ongoing Studies to Watch in Unresectable, Nonmetastatic HCC

EP. 6 Ongoing Studies to Watch in Unresectable, Nonmetastatic HCC

Stephen Lam Chan, MBBS, MD, FRCP, FHKCP, FHKAM, and Gonzalo Cantis, MD, discuss findings from LEAP-012 evaluating lenvatinib plus pembrolizumab combined with TACE in this setting. Chan outlines the biologic rationale for integrating systemic immunotherapy and antiangiogenic therapy with locoregional treatment to enhance tumor necrosis and immune activation. Cantis reviews key efficacy and safety outcomes and considers how this triplet strategy may compare with TACE alone in terms of response, progression control, and tolerability.

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