Opinion|Videos|March 4, 2026
Systemic Therapy and Downstaging in Unresectable, Nonmetastatic HCC
Stephen Lam Chan, MBBS, MD, FRCP, FHKCP, FHKAM, and Gonzalo Cantis, MD, discuss the use of systemic therapy to achieve downstaging in unreeseactable, nonmetastatic HCC.
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Stephen Lam Chan, MBBS, MD, FRCP, FHKCP, FHKAM, and Gonzalo Cantis, MD, explore the evolving role of systemic therapy as a tool for downstaging disease. Chan reviews how immunotherapy-based combinations may increase the likelihood of tumor shrinkage sufficient to permit resection, transplantation, or ablation in selected patients. Cantis emphasizes careful patient selection and multidisciplinary evaluation when considering downstaging strategies, given variability in liver function and procedural eligibility.
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