Daniel H. Ahn, DO, discusses the significance of the phase 3 KEYNOTE-177 trial in patients with microsatellite instability–high metastatic colorectal cancer.
Daniel H. Ahn, DO, an oncologist, internist, and assistant professor of medicine at Mayo Clinic, discusses the significance of the phase 3 KEYNOTE-177 trial in patients with microsatellite instability–high (MSI-H) metastatic colorectal cancer (mCRC).
The study showed a doubling in progression-free survival with pembrolizumab (Keytruda) versus standard chemotherapy in patients with newly diagnosed MSI-H mCRC, Ahn explains.
Prior to these data, a patient with MSI-H mCRC that harbors an NTRK fusion would have received chemotherapy in the frontline setting, followed by either a checkpoint inhibitor or an NTRK-directed TKI, says Ahn.
However, pembrolizumab monotherapy has now become the new frontline standard of care for this subgroup ofpatients, Ahn concludes.