Video

Dr. Anders on Navigating the Treatment Landscape of Metastatic TNBC

Carey K. Anders, MD, discusses navigating the treatment landscape of metastatic triple-negative breast cancer.

Carey K. Anders, MD, medical oncologist, medical director, Brain and Spine Metastases Program, Duke Cancer Center, Duke Health, discusses navigating the treatment landscape of metastatic triple-negative breast cancer (mTNBC).

Several factors should be considered when selecting treatment for a patient with mTNBC, Anders explains. These factors include the patient’s symptom burden, their baseline health status, and the tolerability of the therapy. Additionally, patient preference is an important factor to consider during the decision-making process, Anders adds. 

Moreover, from a biological perspective, it is important understand whether the patient is PD-L1 positive or negative. Patients with PD-L1–positive disease are eligible to receive up-front chemoimmunotherapy, whereas patients with PD-L1–negative disease receive single-agent chemotherapy in the frontline setting, Anders explains.

In the second- and later-line settings, the antibody-drug conjugate sacituzumab govitecan-hziy (Trodelvy) or clinical trials may be considered, Anders concludes.

Related Videos
Jonathan Spicer, MD, PhD, FRCS
Daniel DeAngelo, MD, PhD
Marc J. Braunstein, MD, PhD, associate professor, Department of Medicine, co-director, Hematology-Oncology System, New York University (NYU) Grossman Long Island School of Medicine
Douglas W. Sborov, MD, MS, associate professor, Department of Internal Medicine—Division of Hematology and Hematologic Malignancies; director, Hematology Disease Center and Plasma Cell Dyscrasias Program, the University of Utah Huntsman Cancer Institute
Bradley C. Carthon, MD, PhD
David C. Fisher, MD
Alan Tan, MD
Binod Dhakal, MD
Sheldon M. Feldman, MD
Yair Lotan, MD, UT Southwestern Medical Center