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Giada Bianchi, MD, discusses diagnostic factors for light chain amyloidosis.
Giada Bianchi, MD, a physician at Dana-Farber Cancer Institute, and an instructor in medicine at Harvard Medical School, discusses diagnostic factors for light chain (AL) amyloidosis.
Diagnostic delay remains as a notable challenge in AL amyloidosis, according to Bianchi. Patients who have advanced cardiac involvement often express disease symptoms for months and possibly years, Bianchi explains. Notably, this disease is a mimicker and can present with subtle symptoms at the outset, which can make the diagnostic process challenging, she says.
Depending on the organ that is involved, patients can present with a variety of symptoms. As such, it is important to be aware that any patient who has progressive symptoms of unclear nature, particularly those with smoldering myeloma, should be screened for AL amyloidosis, Bianchi concludes.