Dr. Borghaei on Selecting Single-Agent Versus Combination Therapy in Lung Cancer

Video

Hossein Borghaei, DO, MS, discusses selecting between single-agent versus combination therapies in lung cancer.

Hossein Borghaei, DO, MS, chief, Division of Thoracic Medical Oncology, director, Lung Cancer Risk Assessment, professor, Department of Hematology/Oncology, co-director, Immune Monitoring Facility, Lung Cancer and Mesothelioma TRDG member, and Gloria and Edmund M. Dunn Chair in Thoracic Oncology, Fox Chase Cancer Center, discusses selecting between single-agent versus combination therapeutic approaches in lung cancer.

Single-agent therapies that are supported by clinical data are recommended for patients who are likely to achieve disease control with 1 drug, Borghaei says. Approved chemoimmunotherapy or immunotherapy combinations have demonstrated manageable safety profiles and should be considered in appropriate patients, Borghaei explains. Currently, PD-L1 expression can be used to inform which patients should receive combination regimens; however, additional biomarkers are needed, concludes Borghaei.

Related Videos
Raj Singh, MD
Arya Amini, MD
Patrick I. Borgen, MD
Kari Hacker, MD, PhD, NYU Grossman School of Medicine
Janos L. Tanyi, MD, PhD, associate professor, Obstetrics and Gynecology, Hospital of the University of Pennsylvania
Reshma Lillaney Mahtani, DO
Christian Marth, MD, PhD, head, professor, Department of Obstetrics and Gynecology, Innsbruck Medical University
Mansoor Raza Mirza, MD, chief oncologist, Department of Oncology, Rigshospitalet, Copenhagen University Hospital
Judy Hayek, MD, gynecologic oncology fellow, State University of New York (SUNY) Downstate College of Medicine
Leslie M. Randall, MD, MAS, professor, division head, Department of Obstetrics and Gynecology – Gynecologic Oncology, Virginia Commonwealth University School of Medicine Obstetrics and Gynecology