Video

Dr. Bunn on Missed Endpoint for Nivolumab in CheckMate-026 for NSCLC

Paul A. Bunn Jr, MD, Distinguished Professor, Division of Medical Oncology/University of Colorado, James Dudley Chair in Lung Cancer Research, University of Colorado Denver, 2014 Giant of Cancer Care in Lung Cancer, discusses the phase III results from CheckMate-026, which explored nivolumab (Opdivo) monotherapy in treatment-naïve patients with advanced non–small cell lung cancer.

Paul A. Bunn Jr, MD, Distinguished Professor, Division of Medical Oncology/University of Colorado, James Dudley Chair in Lung Cancer Research, University of Colorado Denver, 2014 Giant of Cancer Care in Lung Cancer, discusses the phase III results from CheckMate-026, which explored nivolumab (Opdivo) monotherapy in treatment-naïve patients with advanced non—small cell lung cancer (NSCLC).

Earlier immunotherapy trials studied nivolumab, pembrolizumab (Keytruda), and atezolizumab (Tecentriq) in the second-line setting, Bunn explains, adding that all 3 agents were found to be favorable over chemotherapy. When these antibodies were moved into first-line studies, people with no PD-L1 expression were excluded. However, the CheckMate-026 study enrolled patients with PD-1 positivity ≥ 5%.

In CheckMate-026, results showed that nivolumab missed its primary endpoint of progression-free survival (PFS); moreover, Bunn says, PFS is not an appropriate endpoint. Additionally, the trial could end up having an improvement in overall survival. Full data will be presented at an upcoming medical meeting. CheckMate-227, Bunn says, is an ongoing frontline combination trial of nivolumab and ipilimumab (Yervoy) in the first-line setting that will likely need to be modified following these initial findings.

<<<

View more from the 2016 International Lung Cancer Congress

Related Videos
Leah Backhus, MD, MPH, FACS, professor, University Medical Line, Cardiothoracic Surgery, co-director, Thoracic Surgery Clinical Research Program, associate program director, Thoracic Track, CT Surgery Residency Training Program, Thelma and Henry Doelger Professor of Cardiovascular Surgery, Stanford Medicine; chief, Thoracic Surgery, VA Palo Alto
Roy S. Herbst, MD, PhD, Ensign Professor of Medicine (Medical Oncology), professor, pharmacology, deputy director, Yale Cancer Center; chief, Medical Oncology, director, Center for Thoracic Cancers, Yale Cancer Center and Smilow Cancer Hospital; assistant dean, Translational Research, Yale School of Medicine
A panel of 4 experts on lung cancer
A panel of 4 experts on lung cancer
5 KOLs are featured in this peer exchange
5 KOLs are featured in this peer exchange
Sheldon M. Feldman, MD
Rita Mukhtar, MD
Lajos Pusztai, MD, DPhil
Hope S. Rugo, MD