Video

Dr. Chaudhry on Unmet Needs in Relapsed/Refractory Multiple Myeloma

Maria Chaudhry, MBBS, discusses unmet needs in relapsed/refractory multiple myeloma.

Maria Chaudhry, MBBS, a hematologist at The Ohio State University Comprehensive Cancer Center—James, discusses unmet needs in relapsed/refractory multiple myeloma.

The unmet need in multiple myeloma is largely with patients who have relapsed/refractory disease. This is because at second relapse and later, patients have difficult-to-control disease with toxicities that add up, explains Chaudhry. Patients who relapse within the next 2 years will have received bortezomib (Velcade) or carfilzomib (Kyprolis) as frontline therapy, which allows an anti-CD38 agent in the relapsed/refractory setting to still be relevant, says Chaudhry.

Additionally, data from the CANDOR trial looking at daratumumab (Darzalex), carfilzomib, and dexamethasone are promising and suggest a regimen free of immunomodulatory drugs. Chaudhry plans on using this regimen in her practice and anticipates daratumumab will be increasingly used in the frontline setting. When these patients relapse, they will require agents with different mechanisms of action, according to Chaudhry.

Clinical trials looking at different drugs in multiple myeloma continues, including studies evaluating monoclonal antibodies and bispecific T-cell engagers that target plasma cells. Chaudhry believes a few of these drugs may be FDA approved in 2020, providing this patient population with more options should they relapse.

Newsletter

Stay up to date on the most recent and practice-changing oncology data

Latest CME

View All
Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC
Video

Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC

Jun 6th 2025 - Jul 12th 2025

online-activity
Medical Crossfire®: Expert Perspectives on Targeting c-Met Overexpression and 𝘔𝘌𝘛 Genomic Alterations in NSCLC – Unveiling the Complexities of 𝘔𝘌𝘛 Dysregulation
Video

Medical Crossfire®: Expert Perspectives on Targeting c-Met Overexpression and 𝘔𝘌𝘛 Genomic Alterations in NSCLC – Unveiling the Complexities of 𝘔𝘌𝘛 Dysregulation

Jun 6th 2025 - Jul 12th 2025

online-activity
Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing
Video

Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing

Jun 5th 2025 - Jul 12th 2025

online-activity