Video

Dr. Dean on Remaining Challenges in DLBCL

Author(s):

Robert M. Dean, MD, discusses remaining challenges in diffuse large B-cell lymphoma.

Robert M. Dean, MD, assistant professor, Department of Medicine, School of Medicine, member, Hematopoietic and Immune Cancer Biology Program, Case Comprehensive Cancer Center, physician, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, discusses remaining challenges in diffuse large B-cell lymphoma (DLBCL).

The recent approvals of polatuzumab vedotin-piiq (Polivy), selinexor (Xpovio), and the combination of tafasitamab-cxix (Monjuvi) and lenalidomide (Revlimid) have left the question of optimal sequencing unanswered for patients with DLBCL, Dean explains. Additionally, the generalizability of the results of the phase 2 trials that led to the approvals remains largely unknown, Dean says.

Patients who have relapsed after an autologous stem cell transplant and CAR T-cell therapy and who are still eligible for additional therapy may be candidates for these newer regimens, Dean explains. However, treatment selection depends on the goals of the patient and the toxicity profiles of the agents.

Generating additional data to inform treatment selection beyond patient assessment may alleviate sequencing challenges in DLBCL, concludes Dean.

Newsletter

Stay up to date on the most recent and practice-changing oncology data

Latest CME

View All
Medical Crossfire®: Expert Perspectives on Targeting c-Met Overexpression and 𝘔𝘌𝘛 Genomic Alterations in NSCLC – Unveiling the Complexities of 𝘔𝘌𝘛 Dysregulation
Video

Medical Crossfire®: Expert Perspectives on Targeting c-Met Overexpression and 𝘔𝘌𝘛 Genomic Alterations in NSCLC – Unveiling the Complexities of 𝘔𝘌𝘛 Dysregulation

Jun 6th 2025 - Jul 12th 2025

online-activity
Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC
Video

Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC

Jun 6th 2025 - Jul 12th 2025

online-activity
Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing
Video

Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing

Jun 5th 2025 - Jul 12th 2025

online-activity