Dr. Garcia on the Role of Navitoclax in Myelofibrosis

In Partnership With:

Jacqueline S. Garcia, MD,discusses how navitoclax differs from other agents in primary or secondary myelofibrosis.

Jacqueline S. Garcia, MD, instructor in Medicine, Department of Medical Oncology, Harvard Medical School, and physician, Dana-Farber Cancer Institute, discusses how navitoclax differs from other agents in primary or secondary myelofibrosis.

Navitoclax is an oral BH3 memetic that targets cells that are dependent on BCL-XL and not as dependent on BCL-2 and BCL-W, explains Garcia. This therapy shows that myelofibrosis cells undergo apoptotical priming, and there’s evidence for the activity of BCL-XL inhibition in reversing fibrosis and causing apoptosis, says Garcia.

In preclinical models, there has also been activity with BCL-XL inhibition and JAK2-mutant and -resistant models, according to Garcia. There is evidence of synergy when BCL-XL inhibitors and JAK2 inhibitors, such as ruxolitinib, are combined. Additionally, navitoclax as an oral therapy makes the combination interesting, concludes Garcia.

Related Videos
Amandeep Godara, MBBS
Eunice Wang, MD
Yvonne Chao, MD, PhD
Ruth M. O’Regan, MD, professor, chair, Charles Ayrault Dewey Professorship of Medicine, Department of Medicine, the University of Rochester, physician-in-chief, Strong Memorial Hospital, associate director, Education and Mentoring, the Wilmot Cancer Institute at University of Rochester,
Timothy Burns, MD, PhD, associate professor of medicine, associate program director, Research, associate program director, Hematology/Oncology Fellowship Program, Department of Medicine, Division of Hematology-Oncology, UPMC Hillman Cancer Center
Sapna Patel, BA, MD
Brian Henick, MD
R. Lor Randall, MD, FACS
Edward B. Garon, MD, MS, professor of medicine, Department of Medicine, Division of Hematology/Oncology, David Geffen School of Medicine, the University of California, Los Angeles (UCLA), UCLA Health
Matthew Brunner, MD, assistant professor, hematologic specialist, medical oncology, and palliative care, Department of Medicine, University of Wisconsin Carbone Cancer Center
Related Content