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Dr. Haseebuddin on PD-1 Expression on Monocytes in RCC

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Partner | Cancer Centers | <b>Fox Chase Cancer Center</b>

Mohammed Haseebuddin, MD, a fellow in Urologic Oncology at Fox Chase Cancer Center, discusses the overall significance of a study examining an elevated preoperative classical monocyte PD-1 mean fluorescence intensity level in patients with clear cell renal cell carcinoma.

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Mohammed Haseebuddin, MD, a fellow in Urologic Oncology at Fox Chase Cancer Center, discusses the overall significance of a study examining an elevated preoperative classical monocyte PD-1 mean fluorescence intensity level in patients with clear cell renal cell carcinoma (RCC).

There are 3 different types of monocytes, Haseebuddin explains, which are classical, intermediate, and non-classical. It is thought that the classical monocytes resemble proinflammatory monocytes, which then enter the tissue and act against cancer. All 3 of these monocytes play a role, he adds.

Regarding this study, researchers believed that PD-1 expression in select patient populations affects survival, leading to the idea that if monocytes seem to play a central role in the immune system, then perhaps PD-1 expression on monocytes are important for survival.


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