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Jeremy C. Jones, MD, discusses the importance of testing for microsatellite instability high in colorectal cancer.
Jeremy C. Jones, MD, hematologist/oncologist, Mayo Clinic, discusses the importance of testing for microsatellite instability high (MSI-H) in colorectal cancer (CRC).
All patients with CRC, including those without metastatic disease, should undergo molecular testing to determine MSI-H status, says Jones. Testing is commonly performed by immunohistochemistry or polymerase chain reaction assays, Jones adds.
Although MSI-H tumors account for approximately 5% of all CRC, this patient subgroup has demonstrated dramatic response rates with checkpoint inhibitor therapy, Jones explains. As such, it is critical to ensure patients with MSI-H CRC are appropriately identified and treated with checkpoint inhibitors, such as pembrolizumab (Keytruda), concludes Jones.