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Opinion|Videos|July 15, 2024

Dr Locke Shares Key Takeaways from ZUMA-7 and TRANSFORM Studies

Author(s)Matthew A. Lunning, DO, FACP, University of Nebraska Medical Center, Elizabeth Budde, MD, PhD, Leo I. Gordon, MD, Robert H. Lurie Comprehensive Cancer Center

An examination of results from key studies in the DLBCL landscape are conducted by Dr Fred Locke.

Episodes in this series

EP. 1 Navigating Second-Line Treatments and CAR T-Cell Therapy for DLBCL: Insights from Dr. Budde and Dr. Lunning

EP. 1 Navigating Second-Line Treatments and CAR T-Cell Therapy for DLBCL: Insights from Dr. Budde and Dr. Lunning

EP. 2 Dr Locke, Dr Hunter, Dr Lunning Share Referral Patterns in Their Practices

EP. 2 Dr Locke, Dr Hunter, Dr Lunning Share Referral Patterns in Their Practices

EP. 3 Dr Locke Shares Key Takeaways from ZUMA-7 and TRANSFORM Studies

EP. 3 Dr Locke Shares Key Takeaways from ZUMA-7 and TRANSFORM Studies

EP. 4 Dr Gordon Shares Key Takeaways from ALYCANTE and PILOT for 2L CAR T-cell Transplant-Ineligible Population

EP. 4 Dr Gordon Shares Key Takeaways from ALYCANTE and PILOT for 2L CAR T-cell Transplant-Ineligible Population

EP. 5 Dr Hunter Shares Key Takeaways from L-MIND 5-Year Data and RE-MIND2 Study

EP. 5 Dr Hunter Shares Key Takeaways from L-MIND 5-Year Data and RE-MIND2 Study

EP. 6 Panel Discuses Use of CD19 Bispecifics in Sequencing

EP. 6 Panel Discuses Use of CD19 Bispecifics in Sequencing

EP. 7 Panel Discusses Challenges with CAR T Therapy in R/R DLBCL, Particularly Around T-cell Exhaustion

EP. 7 Panel Discusses Challenges with CAR T Therapy in R/R DLBCL, Particularly Around T-cell Exhaustion

EP. 8 Current Approach to Bridging Therapy in R/R DLBCL

EP. 8 Current Approach to Bridging Therapy in R/R DLBCL

EP. 9 Risk of Secondary Malignancies in Heavily Pre-Treated Population

EP. 9 Risk of Secondary Malignancies in Heavily Pre-Treated Population

EP. 10 Management of CRS and ICANS with CAR T-cell Therapy

EP. 10 Management of CRS and ICANS with CAR T-cell Therapy

EP. 11 Third-line Treatment Options for DLBCL After CAR T-cell Therapy or ASCT in Second-line

EP. 11 Third-line Treatment Options for DLBCL After CAR T-cell Therapy or ASCT in Second-line

EP. 12 Contemporary Sequencing CD20xCD3 Bispecific Antibody R/R DLBCL Who Have progressed beyond CAR T-cell therapy

EP. 12 Contemporary Sequencing CD20xCD3 Bispecific Antibody R/R DLBCL Who Have progressed beyond CAR T-cell therapy

EP. 13 Bispecific therapy – treatment setting and management of short-term adverse events

EP. 13 Bispecific therapy – treatment setting and management of short-term adverse events

EP. 14 Bispecific therapy – management of long-term adverse events in the community setting

EP. 14 Bispecific therapy – management of long-term adverse events in the community setting

EP. 15 Practice Patterns and Real Use of Epcoritamab and Glofitamab

EP. 15 Practice Patterns and Real Use of Epcoritamab and Glofitamab

EP. 16 Disparities in access to newer or expensive treatments, unmet needs in the treatment of DLBCL

EP. 16 Disparities in access to newer or expensive treatments, unmet needs in the treatment of DLBCL

Video content above is prompted by the following:

Please discuss the data supporting CAR T-cell therapy as the primary 2Ltreatment option for patients who are transplant-eligible and have primary refractory or early relapse R/R DLBCL.
- Please review the latest 56-month follow-up data of the ZUMA-7study, evaluating axi-cel.
  - ASH 2024 Update: Subgroup Analysis of the ZUMA-7 study.
  - Please discuss the subsequent cellular immunotherapy off-protocol in the SOC arm.
Please review the 36-month follow-up data of the TRANSFORM study, evaluating liso-cel.
- ASCO 2024 Update: Subgroup analysis of the TRANSFORM study [primary refractory vs. early relapsed].
What were some key takeaways from the results of these two studies?

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