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Opinion|Videos|August 5, 2024

Third-line Treatment Options for DLBCL After CAR T-cell Therapy or ASCT in Second-line

Author(s)Matthew A. Lunning, DO, FACP, University of Nebraska Medical Center, Elizabeth Budde, MD, PhD, Leo I. Gordon, MD, Robert H. Lurie Comprehensive Cancer Center

Episodes in this series

EP. 1 Navigating Second-Line Treatments and CAR T-Cell Therapy for DLBCL: Insights from Dr. Budde and Dr. Lunning

EP. 1 Navigating Second-Line Treatments and CAR T-Cell Therapy for DLBCL: Insights from Dr. Budde and Dr. Lunning

EP. 2 Dr Locke, Dr Hunter, Dr Lunning Share Referral Patterns in Their Practices

EP. 2 Dr Locke, Dr Hunter, Dr Lunning Share Referral Patterns in Their Practices

EP. 3 Dr Locke Shares Key Takeaways from ZUMA-7 and TRANSFORM Studies

EP. 3 Dr Locke Shares Key Takeaways from ZUMA-7 and TRANSFORM Studies

EP. 4 Dr Gordon Shares Key Takeaways from ALYCANTE and PILOT for 2L CAR T-cell Transplant-Ineligible Population

EP. 4 Dr Gordon Shares Key Takeaways from ALYCANTE and PILOT for 2L CAR T-cell Transplant-Ineligible Population

EP. 5 Dr Hunter Shares Key Takeaways from L-MIND 5-Year Data and RE-MIND2 Study

EP. 5 Dr Hunter Shares Key Takeaways from L-MIND 5-Year Data and RE-MIND2 Study

EP. 6 Panel Discuses Use of CD19 Bispecifics in Sequencing

EP. 6 Panel Discuses Use of CD19 Bispecifics in Sequencing

EP. 7 Panel Discusses Challenges with CAR T Therapy in R/R DLBCL, Particularly Around T-cell Exhaustion

EP. 7 Panel Discusses Challenges with CAR T Therapy in R/R DLBCL, Particularly Around T-cell Exhaustion

EP. 8 Current Approach to Bridging Therapy in R/R DLBCL

EP. 8 Current Approach to Bridging Therapy in R/R DLBCL

EP. 9 Risk of Secondary Malignancies in Heavily Pre-Treated Population

EP. 9 Risk of Secondary Malignancies in Heavily Pre-Treated Population

EP. 10 Management of CRS and ICANS with CAR T-cell Therapy

EP. 10 Management of CRS and ICANS with CAR T-cell Therapy

EP. 11 Third-line Treatment Options for DLBCL After CAR T-cell Therapy or ASCT in Second-line

EP. 11 Third-line Treatment Options for DLBCL After CAR T-cell Therapy or ASCT in Second-line

EP. 12 Contemporary Sequencing CD20xCD3 Bispecific Antibody R/R DLBCL Who Have progressed beyond CAR T-cell therapy

EP. 12 Contemporary Sequencing CD20xCD3 Bispecific Antibody R/R DLBCL Who Have progressed beyond CAR T-cell therapy

EP. 13 Bispecific therapy – treatment setting and management of short-term adverse events

EP. 13 Bispecific therapy – treatment setting and management of short-term adverse events

EP. 14 Bispecific therapy – management of long-term adverse events in the community setting

EP. 14 Bispecific therapy – management of long-term adverse events in the community setting

EP. 15 Practice Patterns and Real Use of Epcoritamab and Glofitamab

EP. 15 Practice Patterns and Real Use of Epcoritamab and Glofitamab

EP. 16 Disparities in access to newer or expensive treatments, unmet needs in the treatment of DLBCL

EP. 16 Disparities in access to newer or expensive treatments, unmet needs in the treatment of DLBCL

Video content above is prompted by the following:

Please give an overview of treatment options for a patient who received 2L treatment with either CAR T-cell therapy or ASCT and has relapsed.
- What would be your treatment choice in the third line?
- What key issues do you consider in your sequencing decisions?
- Please discuss rationales for each:
Monoclonal antibody—tafasitamab?
ADC —loncastuximab, polatuzumab?
Would you go to CAR T after ASCT?
Bispecific antibody—epcoritamab or glofitamab?

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