Dr. McArthur Discusses Subpopulation Data from coBRIM Trial in Advanced Melanoma

Video

Grant McArthur, PhD, discusses significant results from the final analysis of the coBRIM trial, which evaluated the 5-year survival data of cobimetinib plus vemurafenib in patients with BRAF V600-mutated advanced melanoma.

Grant McArthur, PhD, Melanoma Unit, Peter MacCallum Cancer Centre, discusses significant results from the final analysis of the coBRIM trial, which evaluated the 5-year survival data of cobimetinib (Cotellic) plus vemurafenib (Zelboraf) in patients with BRAF V600-mutated advanced melanoma.

In an analysis of subpopulations, McArthur says all patients did receive benefit from the combination versus monotherapy treatment. However, patients with an elevated lactate dehydrogenase (LDH) had less benefit in terms of long-term survival outcomes. Forty-three percent of patients with a normal LDH at baseline were alive at 5 years, while 16% with an elevated LDH remained alive. This is a striking difference, McArthur notes.

Related Videos
Patrick I. Borgen, MD
Kari Hacker, MD, PhD, NYU Grossman School of Medicine
Janos L. Tanyi, MD, PhD, associate professor, Obstetrics and Gynecology, Hospital of the University of Pennsylvania
Reshma Lillaney Mahtani, DO
Christian Marth, MD, PhD, head, professor, Department of Obstetrics and Gynecology, Innsbruck Medical University
Mansoor Raza Mirza, MD, chief oncologist, Department of Oncology, Rigshospitalet, Copenhagen University Hospital
Judy Hayek, MD, gynecologic oncology fellow, State University of New York (SUNY) Downstate College of Medicine
Leslie M. Randall, MD, MAS, professor, division head, Department of Obstetrics and Gynecology – Gynecologic Oncology, Virginia Commonwealth University School of Medicine Obstetrics and Gynecology
Dimitrios Nasioudis, MD, fellow, Gynecologic Oncology, Perelman School of Medicine, the University of Pennsylvania
Sara Corvigno, MD, PhD, translational researcher, oncology, The University of Texas MD Anderson Cancer Center