Dr. O’Shaughnessy on the Utility of Tucatinib in the HER2+ Breast Cancer Brain Metastases

Publication
Video
Supplements And Featured PublicationsAntibody-Drug Conjugates in HER2+ Breast Cancer
Volume 1
Issue 1

In Partnership With:

Joyce A. O'Shaughnessy, MD, discusses the utility of tucatinib in HER2-positive breast cancer with brain metastases.

Joyce A. O'Shaughnessy, MD, chair of Breast Cancer Research and chair of Breast Cancer Prevention Research at Baylor-Sammons Cancer Center of Texas Oncology, as well as the 2016 Giant of Cancer Care® in Community Outreach, discusses the utility of tucatinib (Tukysa) in HER2-positive breast cancer with brain metastases.

An update on the phase 2 HER2CLIMB trial was presented during the 2020 ASCO Virtual Scientific Program. In this trial, the selective HER2-targeted TKI tucatinib was added to capecitabine plus trastuzumab (Herceptin) versus capecitabine, trastuzumab, and placebo, says O’Shaughnessy. The update focused specifically on patients who had brain metastases. A total of 174 patients had active brain metastases that were either untreated or treated and progressing.

Results showed that the addition of tucatinib improved progression-free survival (PFS) in the brain metastases themselves, says O'Shaughnessy. Tucatinib not only improved overall PFS, including all of the systemic, metastatic disease, but also substantially reduced progression in the central nervous system; the agent showed powerful penetration and activity in the brain, adds O'Shaughnessy. Importantly, tucatinib also improved the survival of patients with brain metastases compared with those who did not receive the TKI.

These data cemented the importance of tucatinib for use in patients with HER2-positive metastatic breast cancer who have brain metastases, even if they are progressing and active or they have not been treated previously. This allows patients to be spared from radiation therapy for a while, concludes O’Shaughnessy.

Related Videos
Jaime R. Merchán, MD, Sylvester Comprehensive Cancer Center
Rona Yaeger, MD
Jeremy L. Ramdial, MD, assistant professor, Department of Stem Cell Transplantation and Cellular Therapy, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center
Alexandra Gomez Arteaga, MD, Weill Cornell Medicine/New York-Presbyterian Hospital
Rahul Banerjee, MD, FACP, assistant professor, Clinical Research Division, Fred Hutchinson Cancer Center; assistant professor, Division of Hematology and Oncology, University of Washington
Alice Bertaina, MD, PhD
Jeffery Auletta, MD, The Ohio State University College of Medicine
Betty Hamilton, MD, Cleveland Clinic
Stephanie Lee, MD, MPH, Fred Hutchinson Cancer Center