Video

Dr. Patel on a Subgroup Analysis of the NAPOLI-1 Trial in Pancreatic Cancer

Reema A. Patel, MD, discusses the results of a subgroup analysis from the NAPOLI-1 trial in pancreatic cancer.

Reema A. Patel, MD, associate program director, Hematology & Medical Oncology Fellowship, assistant professor of medicine, Division of Medical Oncology, University of Kentucky, discusses the results of a subgroup analysis from the NAPOLI-1 trial in pancreatic cancer.

The phase 3 NAPOLI-1 trial demonstrated a survival benefit with liposomal irinotecan (Onivyde) in combination with 5-fluorouracil (5-FU) and leucovorin versus 5-FU and leucovorin alone in patients with metastatic pancreatic ductal adenocarcinoma who had received prior gemcitabine-based therapy.

A post-hoc subgroup analysis revealed that the majority of patient subgroups responded well to the treatment, Patel explains. However, patients who received prior non-liposomal irinotecan had poorer outcomes versus patients who had no prior irinotecan. Notably, due to the low number of patients who had prior non-liposomal irinotecan, these findings may not be widely applicable in the real-world setting, Patel says.

However, in practice, it may be optimal to give an alternative therapy between non-liposomal irinotecan and liposomal irinotecan to potentially increase the chance of response to liposomal irinotecan, concludes Patel.

Newsletter

Stay up to date on the most recent and practice-changing oncology data

Latest CME

View All
Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC
Video

Tumor Board: Expert Insights on Managing Classical 𝘌𝘎𝘍𝘙 Mutations, 𝘌𝘎𝘍𝘙 Exon 20 Insertions, and Atypical 𝘌𝘎𝘍𝘙 Mutations in Metastatic NSCLC

Jun 6th 2025 - Jul 12th 2025

online-activity
Medical Crossfire®: Expert Perspectives on Targeting c-Met Overexpression and 𝘔𝘌𝘛 Genomic Alterations in NSCLC – Unveiling the Complexities of 𝘔𝘌𝘛 Dysregulation
Video

Medical Crossfire®: Expert Perspectives on Targeting c-Met Overexpression and 𝘔𝘌𝘛 Genomic Alterations in NSCLC – Unveiling the Complexities of 𝘔𝘌𝘛 Dysregulation

Jun 6th 2025 - Jul 12th 2025

online-activity
Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing
Video

Evolving Treatment Strategies in Pancreatic Cancer: Current Standards, Emerging Targets, and the Role of Molecular Testing

Jun 5th 2025 - Jul 12th 2025

online-activity