Video

Dr. Vulfovich on Broad Molecular Profiling in mCRC

Michel Vulfovich, MD, medical director, Sickle Cell Disease and Gynecology Oncology programs, Memorial Healthcare System, discusses the utility of broad molecular profiling in metastatic colorectal cancer (mCRC).

Michel Vulfovich, MD, medical director, Sickle Cell Disease and Gynecology Oncology programs, Memorial Healthcare System, discusses the utility of broad molecular profiling in metastatic colorectal cancer (mCRC).

Single-gene testing is no longer sufficient in mCRC, says Vulfovich. Now, broad molecular testing should be done to screen for BRAF, HER2, and microsatellite instability, in addition to KRAS. Notably, the results can indicate a patient’s prognosis as well as inform treatment.

Typically, patients receive FOLFOX or CAPOX in the frontline setting, says Vulfovich. Depending on whether the tumor is right sided or left sided, bevacizumab (Avastin) can be added, whereas patients with wild-type KRAS mutations are more likely to receive cetuximab (Erbitux) or panitumumab (Vectibix) up front. The results of molecular testing could also impact sequencing strategies in the second- and third-line settings, making testing a necessity upon diagnosis, concludes Vulfovich.

Related Videos
Rene Y. McNall-Knapp, MD, pediatric hematologist-oncologist, Jimmy Everest Center, Oklahoma Children’s Hospital OU Health; professor, Department of Pediatrics, University of Oklahoma Health Sciences Center
John Andrew Livingston, MD, MS
Howard Colman, MD, PhD, Jan M. Huntsman Presidential Professor, Department of Neurosurgery, member, Brain Tumor Research Team, and leader, Center for Neurologic Cancers, Huntsman Cancer Institute, University of Utah
Kathleen N. Moore, MD, MS
Rona Yaeger, MD
 PER® International Symposium on Melanoma and Other Cutaneous Malignancies
Robert
Charles B. Nguyen, MD
YI LIN, MD, PHD
Dr Fakih on the FDA Approval of Sotorasib Plus Panitumumab for KRAS G12C–Mutated mCRC