Dr. Zevallos on Molecular Profile of HPV-Positive Oropharyngeal SCC Stratified by Smoking Status

Name: Dr. Zevallos on Molecular Profile of HPV-Positive Oropharyngeal SCC Stratified by Smoking Status
Uploaded: 2016-02-20T10:50:00.000Z
Description: Jose P. Zevallos, MD, MPH, FACS, assistant professor, director of Oncologic Research, University of North Carolina School of Medicine, discusses a study that examined the molecular profile of patients with HPV-positive oropharyngeal squamous cell carcinoma (SCC) stratified by smoking status.

February 20, 2016

Jose P. Zevallos, MD, MPH, FACS

Video

Jose P. Zevallos, MD, MPH, FACS, assistant professor, director of Oncologic Research, University of North Carolina School of Medicine, discusses a study that examined the molecular profile of patients with HPV-positive oropharyngeal squamous cell carcinoma (SCC) stratified by smoking status.

Using targeted DNA sequencing, researchers sought to determine if patients with HPV-positive disease who were smokers had differing mutational status than those who were both HPV-positive and nonsmokers.

Results showed that there were distinct genomic differences between HPV-positive nonsmokers and HPV-positive smokers. Smokers harbored mutations that mimicked HPV-negative tumors, he adds. This demonstrates that patients who are HPV-positive but have this genetic profile likely will not respond as well to treatment.

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