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Opinion|Videos|October 30, 2025

Emerging Therapies for SCLC

Author(s)Anne Chiang, MD, Ticiana A. Leal, MD

Panelists discuss novel and investigational therapies under study for small cell lung cancer, including immunotherapy combinations and targeted approaches.

Episodes in this series

EP. 1 Introduction and Case 1: Diagnostic Workup of Patients with SCLC

EP. 1 Introduction and Case 1: Diagnostic Workup of Patients with SCLC

EP. 2 Treatment of SCLC Based on Patient Characteristics

EP. 2 Treatment of SCLC Based on Patient Characteristics

EP. 3 Safety and Efficacy of SCLC Treatments Based on Trial Data

EP. 3 Safety and Efficacy of SCLC Treatments Based on Trial Data

EP. 4 Treatment Selection and Monitoring/Maintenance in Patients With SCLC

EP. 4 Treatment Selection and Monitoring/Maintenance in Patients With SCLC

EP. 5 IMforte Trial: Applying the Results in Practice

EP. 5 IMforte Trial: Applying the Results in Practice

EP. 6 Case 2: Treatment of Recurring SCLC With Brain Metastasis and AE Management

EP. 6 Case 2: Treatment of Recurring SCLC With Brain Metastasis and AE Management

EP. 7 Adherence to Treatment, Shared Decision-Making, and Patient Communication

EP. 7 Adherence to Treatment, Shared Decision-Making, and Patient Communication

EP. 8 Case 3: Second-Line Treatment for SCLC

EP. 8 Case 3: Second-Line Treatment for SCLC

EP. 9 Experience With Lurbinectedin in SCLC

EP. 9 Experience With Lurbinectedin in SCLC

EP. 10 Emerging Therapies for SCLC

EP. 10 Emerging Therapies for SCLC

The final segment explores the rapidly advancing research pipeline for small cell lung cancer. Emerging agents targeting transcription regulation, immune modulation, and antibody-drug conjugates represent promising new directions. Early clinical data suggest that these strategies may extend survival and improve disease control beyond what is achievable with current regimens.

Panelists express optimism about the potential for next-generation immunotherapies and bispecific T-cell engagers to transform treatment paradigms. However, they note that robust biomarker validation and patient selection criteria will be key to identifying those most likely to benefit.

The discussion closes on a forward-looking note: Continued innovation and clinical trial participation remain essential to improving long-term outcomes in this aggressive and historically underserved disease.

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