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Opinion|Videos|July 8, 2024

Evolving Best Practices for ESR1 Testing

Author(s)Virginia G. Kaklamani, MD, DSc, Heather McArthur, MD, MPH

The breast cancer experts share their clinical experiences and strategies regarding the optimal timing for testing ESR1 mutations in patients with HR+/HER2- metastatic breast cancer, elaborating on how the specific points in the treatment journey at which they recommend testing influence their subsequent treatment decisions and overall approach to patient management.

Episodes in this series

2 KOLs are featured in this program.

EP. 1 Prevalence and Testing Strategies for ESR1

2 KOLs are featured in this program.

EP. 2 Evolution of Testing Strategies for ESR1

2 KOLs are featured in this program.

EP. 3 Dynamics of ESR1 Alterations and Serial Liquid Biopsies

2 KOLs are featured in this program.

EP. 4 Case Presentation 1: PIK3CA Mutation With ESR1 Mutations

2 KOLs are featured in this program.

EP. 5 EMERALD Study Design and Results for Elacestrant

2 KOLs are featured in this program.

EP. 6 Evolving Best Practices for ESR1 Testing

2 KOLs are featured in this program.

EP. 7 Case Presentation 2: Co-mutations in ESR1 and PIK3CA

2 KOLs are featured in this program.

EP. 8 PIK3CA Mutations and Delivering PI3K Inhibitors

2 KOLs are featured in this program.

EP. 9 PostMONARCH: Dissecting Data on Sequential CDK 4/6 Inhibitors

2 KOLs are featured in this program.

EP. 10 Combinations and Treatment Sequence Strategies in Breast Cancer

2 KOLs are featured in this program.

EP. 11 Future Directions and Unmet Needs in HR+ Breast Cancer

2 KOLs are featured in this program.

EP. 12 Looking Ahead: Expert Future Perspectives in HR+ Breast Cancer

In your clinical practice, at what specific points in the treatment journey would you recommend testing for ESR1 mutations, and how does the timing of testing impact your subsequent treatment decisions and approach?
- What are your institution’s protocols and best practices regarding the timing and frequency of ESR1 mutations testing throughout the treatment journey
  - Can you elaborate further on what an ESR1 mutation is?

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