
Opinion|Videos|July 8, 2024
Evolving Best Practices for ESR1 Testing
The breast cancer experts share their clinical experiences and strategies regarding the optimal timing for testing ESR1 mutations in patients with HR+/HER2- metastatic breast cancer, elaborating on how the specific points in the treatment journey at which they recommend testing influence their subsequent treatment decisions and overall approach to patient management.
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Episodes in this series

- In your clinical practice, at what specific points in the treatment journey would you recommend testing for ESR1 mutations, and how does the timing of testing impact your subsequent treatment decisions and approach?
- What are your institution’s protocols and best practices regarding the timing and frequency of ESR1 mutations testing throughout the treatment journey
- Can you elaborate further on what an ESR1 mutation is?
- What are your institution’s protocols and best practices regarding the timing and frequency of ESR1 mutations testing throughout the treatment journey
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The sNDA for elinzanetant seeks FDA approval for moderate-to-severe vasomotor symptoms in women receiving endocrine therapy for HR-positive breast cancer.

Clinicians and researchers are set to gather for the UCSF-cosponsored International Invasive Lobular Carcinoma Symposium.

Read a refresh of breast cancer FDA news from August 2026, including an sNDA application in PIK3CA-mutant disease and a fast track designation.

The FDA approved imlunestrant plus abemaciclib in breast cancer and photodynamic therapy in skin cancer, and more.

The FDA approved imlunestrant/abemaciclib for ER-positive, HER2-negative, ESR1-mutated advanced breast cancer after progression on endocrine therapy.

Japan approved T-DXd plus pertuzumab for HER2-positive disease and Dato-DXd for triple-negative disease in first-line metastatic breast cancer.
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